21 июня сообщество “Coalition to cure Calpain 3” сделало рассылку новой научной статьи коллектива авторов.
Перевода пока нет, публикуем в оригинале.
Coalition to Cure Calpain 3 (C3) is excited to announce the publication of important research undertaken by Dr. Melissa Spencer, Dr. Irina Kramverova and the Spencer lab: “Failure to up-regulate transcription of genes necessary for muscle adaptation underlies limb girdle muscular dystrophy 2A (calpainopathy).”
In normal muscle, genes are turned on or off in response to exercise. This research shows that, for certain genes, this response is reduced or absent in muscle deficient in calpain 3. This work provides an important clue to help researchers understand why mutations in the gene for calpain 3 cause LGMD2A.
This work was funded, in part, by a research grant from C3.
C3 was founded in October 2010 to fulfill a mission to fund high potential research and clinical trials while educating the global community about the muscle-wasting disease LGMD2A (limb girdle muscular dystrophy type 2A), also known as calpainopathy.